Our Core Service

340B Operational Analysis and Optimization

Identify revenue leakage, workflow inefficiencies, compliance risks, and sustainable growth opportunities within your 340B program.
Service Overview

End-to-End Support for 340B Success

Find the gaps, improve performance, and reinvest more into your mission.

Your 340B program should do more than generate savings.

It should expand healthcare access, support your mission, strengthen your organization, and create sustainable resources that can be reinvested into patient care.

Thrive340B conducts comprehensive operational analyses to help covered entities understand:

  • How their programs are performing
  • Where opportunities may be missed
  • Where revenue may be leaking
  • Where workflows may be inefficient
  • Where compliance risk may exist
  • What changes may support long-term growth

We evaluate the entire program—not only pharmacy revenue—to identify the relationship between clinical services, patient engagement, compliance, operations, financial performance, and community impact.

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A Comprehensive Review of Your 340B Program

Many organizations receive separate reports from pharmacies, third-party administrators, wholesalers, consultants, and internal departments but lack a unified view of overall program performance.

Thrive340B brings these components together.

We review:

  • How patients enter the program
  • How eligibility is determined
  • How providers are added and removed
  • How prescriptions are identified
  • How vendors process claims
  • How replenishment occurs
  • How revenue is collected
  • How financial activity is reconciled
  • How compliance is monitored
  • How savings are reinvested into the mission

What We Analyze

340B Revenue and Savings Streams

We review existing revenue and savings sources to determine how the program is performing across pharmacies, locations, providers, payers, and service lines.

The analysis may include:

  • Retail contract pharmacy activity
  • Specialty pharmacy activity
  • Entity-owned pharmacy activity
  • Provider-level performance
  • Location-level performance
  • Drug-level trends
  • Payer mix
  • Reversal patterns
  • Uninsured patient activity
  • Vendor fees
  • Pharmacy fees
  • Net retained revenue
  • Revenue and savings trends

Revenue Leakage

Revenue leakage can occur when eligible activity is not captured, data is incomplete, providers are missing from systems, claims are incorrectly excluded, or vendor processes are not properly aligned.

We evaluate potential leakage involving:

  • Missing providers
  • Incorrect provider identifiers
  • Incomplete patient data
  • Unmatched encounters and prescriptions
  • Excluded claims
  • Inaccurate location information
  • Contract pharmacy configuration
  • Missed specialty opportunities
  • Delayed replenishment
  • Reversals
  • Rejected claims
  • Vendor reconciliation issues
  • Incomplete data feeds
  • Unresolved exceptions

Any recommended changes remain subject to patient eligibility, covered entity policies, and applicable 340B requirements.

Operational Workflows

We evaluate how work moves between clinical, pharmacy, billing, administrative, compliance, and leadership teams.

This may include:

  • Patient intake
  • Eligibility determination
  • Provider onboarding
  • Provider termination
  • Prescription processing
  • Contract pharmacy communication
  • Vendor data transmission
  • Financial reconciliation
  • Audit preparation
  • Corrective-action management
  • Leadership reporting
  • Staff accountability

Vendor Performance

Third-party administrators, pharmacies, consultants, wholesalers, and other vendors play a significant role in program performance.

We help assess:

  • Contract terms
  • Fee structures
  • Reporting quality
  • Data accuracy
  • Claims capture
  • Service responsiveness
  • Reconciliation processes
  • Compliance responsibilities
  • Performance benchmarks
  • Escalation procedures
  • Corrective-action responsiveness
  • Overall value to the covered entity

Clinical Program Alignment

A successful 340B program should be connected to the organization’s clinical strategy.

We evaluate opportunities involving:

  • HIV prevention and PrEP
  • HIV treatment
  • Hepatitis C care
  • STI services
  • Behavioral health
  • Medication access
  • Uninsured patient support
  • Telemedicine
  • Patient navigation
  • Retention in care
  • Community-based services

Community Impact and Mission Alignment

The value of a 340B program should be evaluated within the context of the covered entity’s mission.

We help organizations measure and communicate how program resources support services such as:

  • HIV prevention and treatment
  • Hepatitis C treatment
  • STI testing and treatment
  • Behavioral healthcare
  • Medication assistance
  • Case management
  • Transportation support
  • Uninsured patient services
  • Community outreach
  • Expanded clinical access
  • Staff and provider capacity
  • New service locations

From Analysis to Action

Our work does not end with a report.

Thrive340B develops practical recommendations based on the organization’s resources, compliance obligations, clinical capacity, market, and strategic priorities.

Recommendations may include:

  • Workflow redesign
  • Provider roster corrections
  • Contract pharmacy changes
  • Vendor renegotiation
  • Financial reconciliation improvements
  • New clinical service lines
  • Turnkey telemedicine program development
  • Specialty pharmacy strategies
  • Patient-retention initiatives
  • Data-reporting improvements
  • Internal accountability structures
  • Community reinvestment planning
  • Leadership reporting systems
  • Compliance-control enhancements

Measure What Matters

Depending on the engagement, Thrive340B can help establish performance indicators involving:

  • Eligible patient growth
  • Prescription capture
  • Net 340B revenue or savings
  • Provider productivity
  • Patient retention
  • Medication initiation
  • Treatment completion
  • Viral suppression
  • Hepatitis C cure rates
  • PrEP persistence
  • Laboratory completion
  • Uninsured patients served
  • Community reinvestment
  • Compliance findings
  • Corrective-action completion
  • Vendor performance

Identify Opportunities Without Compromising Compliance

Optimization does not mean maximizing every possible prescription.

It means ensuring that eligible activity is identified accurately, vendors perform as expected, clinical programs operate effectively, and the organization does not lose resources because of preventable operational failures.

Thrive340B helps covered entities pursue sustainable growth while protecting program integrity.

Build a Financially Strong and Mission-Driven Program

A well-operated 340B program can create meaningful resources for underserved patients and communities.

Sustainable growth requires:

  • Accurate data
  • Efficient workflows
  • Strong compliance controls
  • Effective vendor management
  • Aligned clinical and pharmacy operations
  • Measurable performance
  • Responsible reinvestment

Thrive340B helps covered entities understand where they are today and develop a practical strategy for where the program can go next.

Discover Your Program’s Potential

Ready to Maximize Your 340B Program?

Schedule a consultation to learn how we can help your organization thrive.